Bio

Biostatistics

I am an Assistant Professor and Applied Biostatistician in the Department of Oncology and the Department of Health Research Methods, Evidence, & Impact (formerly Clinical Epidemiology & Biostatistics) at McMaster University in Hamilton, Ontario, Canada.

I completed an MSc degree (Biostatistics) in the Department of Epidemiology and Biostatistics at the University of Western Ontario, and PhD in Health Research Methods (Biostatistics) in the department of Clinical Epidemiology & Biostatistics at McMaster University.

Research

My research interests are in randomized controlled trials and diagnostic accuracy studies. I have extensive experience in the design, conduct, monitoring, statistical analysis and reporting of multi-centre randomized trials, and as a member of various Data Safety Monitoring Boards (DSMB).

I am a faculty biostatistician with the Ontario Clinical Oncology Group (OCOG), an academic cooperative clinical trials methods and coordinating group that works with a network of national and international investigators to design and carry out clinical trials in the fields of cancer and thrombosis. I am the principal statistician for many trials of these trials. For a full list of OCOG studies, please visit OCOG-Trials.

My other research activities include collaborating and consulting with investigators on various research initiatives (clinical trials, diagnostic studies, pilot and feasibility studies, systematic reviews and meta-analyses etc. ) in other areas such as emergency medicine, surgery, cardiology and nephrology.

Publications

Recent peer-reviewed publications:

Griffiths CD, Xu K, Wang J, McKechnie T, Gafni A, Parpia S, Ruo L, Serrano PE. Laparoscopic hepatectomy is safe and effective for the management of patients with colorectal cancer liver metastases in a population-based analysis in Ontario, Canada. A Retrospective Cohort Study. International Journal of Surgery. 2020; 83: 47-52. doi: 10.1016/j.ijsu.2020.08.052. PMID: 32927139
Shahi J, Peng J, Donovan E, Vansantvoort J, Wong R, Tsakiridis T, Quan K, Parpia S, Swaminath A. Overall and chemotherapy-free survival following stereotactic body radiation therapy for abdominopelvic oligometastases. Journal of Medical Imaging and Radiation Oncology. 2020; 64(4):563-569. doi: 10.1111/1754-9485.13057. PMID: 32497405
Takada T, van Doorn S, Parpia S, de Wit K, Anderson DR, Stevens SM, Woller SC, Ten Cate-Hoek AJ, Elf JL, Kraaijenhagen RA, Schutgens REG, Wells PS, Kearon C, Moons KGM, Geersing GJ. Diagnosing deep vein thrombosis in cancer patients with suspected symptoms: An individual participant data meta-analysis. Journal of Thrombosis and Haemostasis. 2020; 18(9):2245-2242. doi: 10.1111/jth.14900. PMID: 32433797
Wang J, Griffiths C, Simunovic M, Parpia S, Gu CS, Gafni A, Ruo L, Hallet J, Bogach J, Serrano PE. Simultaneous versus staged resection for synchronous colorectal liver metastases: A population-based cost analysis in Ontario, Canada – Health economic evaluation. International Journal of Surgery. 2020; 78: 75-82. doi: 10.1016/j.ijsu.2020.04.044. PMID: 32335234
Arsenault J, Parpia S, Goldberg M, Rakovitch E, Reiter H, Doherty M, Lukka H, Sussman J, Wright J, Julian J, Whelan TJ. Acute Toxicity and Quality of Life of Hypofractionated Radiotherapy for Breast Cancer. International Journal of Radiation Oncology Biology Physics. 2020; 107 (5): 943-948. doi: 10.1016/j.ijrobp.2020.03.049. PMID: 32334033
de Wit, K., Parpia, S., Varner, C., Worster, A., McLeod, S., Clayton, N., Kearon, C. and Mercuri, M.  Clinical Predictors of Intracranial Bleeding in Older Adults Who Have Fallen: A Cohort Study. Journal of the American Geriatric Society. 2020; 68(5): 970-976. doi:10.1111/jgs.16338. PMID: 32010977
Medeiros SK, Emery B, Bhagirath V, Parpia S, Dwivedi DJ, Dwivedi NJ, Kearon C, Liaw PC. Does cell-free DNA promote coagulation and inhibit fibrinolysis in patients with unprovoked venous thromboembolism? Thrombosis Research. 2020; 186:13-9. doi: 10.1016/j.thromres.2019.11.030. PMID: 31838139
Parpia, S, Takach Lapner, S, Schutgens, R, Elf, J, Geersing, G‐J, Kearon, C. Clinical pre‐test probability adjusted versus age‐adjusted D‐dimer interpretation strategy for DVT diagnosis: A diagnostic individual patient data meta‐analysis. Journal of Thrombosis and Haemostasis. 2020; 18: 669– 675. https://doi.org/10.1111/jth.14718. PMID: 31869505
Bogach J, Wang J, Griffiths C, Parpia S, Saskin R, Hallet J, Ruo L, Simunovic M, Serrano P. Simultaneous Versus Staged Resection For Synchronous Colorectal Liver Metastases: A Population-Based Cohort Study. International Journal of Surgery. 2020: 74:68-75. doi: 10.1016/j.ijsu.2019.12.009. PMID: 31843676

A full list of my publications can be found on my here.

Teaching/Student Supervision

I contribute to teaching biostatistics and health research methods in the graduate Health Research Methodology Program (HRM) in the Department of Health Research Methods, Evidence, & Impact at McMaster University. Currently, I contribute to the following courses:

HRM 730 – Introduction to Research Methods for Randomized Controlled Trials
HRM 733 – Statistical and Methodological Issues in Randomized Clinical Trials
HRM 739 – Biostatistical Collaboration
HRM 723 – Regression Analysis
HRM 777 – Methods for Diagnostic and Prognostic Research

In addition, I supervise graduate students (MSc and PhD) through the HRM program as well.

Biostatistical Consultancy

Advise and assist individuals and organizations on:

Research methodology
Study design, protocol development
Data collection
Data/statistical analysis
Evidence synthesis

Resources

Statistical and Methodological Blogs & Resources

datamethods.org – discussion forum for data methodologists, clinical trialists and clinical researchers
Statistical Thinking – Frank Harrell
Statistical Modeling, Causal Inference, and Social Science – Andrew Gelman
The Stats Geek – Jonathan Bartlett
Winton Centre for Risk and Evidence Communication – Winton Centre
Error Statistics Philosophy – Deborah Mayo

Contact

Feel free to get in touch with me regarding collaboration, graduate student supervision or statistical consulting.