I collaborate and consult on diverse health research projects where I work with researchers to design studies with the appropriate methodology and statistical analysis to answer the research question. Projects include randomized trials, diagnostic studies, pilot and feasibility studies, systematic reviews and meta-analysis, and clinical decision and prediction rules in clinical areas such as cancer, venous thromboembolism, surgery, critical care and emergency medicine.
Select ongoing projects for which I am the lead statistician.
C-TRACT Trial: Chronic Venous Thrombosis: Relief With Adjunctive Catheter-Directed Therapy
A randomized trial to to determine if the use of image-guided, endovascular therapy (EVT) is an effective strategy with which to reduce Post Thrombotic Syndrome (PTS) disease severity and improve quality of life in patients with established disabling iliac-obstructive post thrombotic syndrome (DIO-PTS). Funded by: National Institutes of Health
RAPID 2: A Randomized Trial of Partial Breast Irradiation
A non-inferiority randomized trial to determine if external beam APBI using given once-a-day over 5 days is not inferior to WBI given once-a-day over 3-5 weeks following BCS in women with node negative invasive breast cancer or DCIS <3cm in size. Funded by: Canadian Institutes of Health Research
ELISA: Prospective Evaluation of Breast-Conserving Surgery Alone in Low Risk Ductal Carcinoma in Situ Defined by a Molecular Expression Assay Combined with Clinico-Pathological Features
A single arm study is to determine if women >45 years of age with DCIS ≤ 2.5 cm and clear margins of excision after breast-conserving surgery alone and an Oncotype DX DCIS Score <39 have a low risk of local recurrence. Funded by: Canadian Institutes of Health Research
FALLS: Derivation of a clinical decision rule for emergency department head CT scanning in seniors who have fallen.
To derive a clinical decision rule which will identify senior patients who present to the ED after a fall who are not at risk of intracranial bleeding, and do not require a head CT scan. Funded by: Canadian Institutes of Health Research
RHEAL: Randomized Trial of Hypofractionated Regional Radiotherapy for Breast Cancer
To determine if hypofractionated RT delivered over 1 week to the breast or chest wall and regional nodes (26Gy in 5 daily fractions to the breast or chest wall and IMNs with 25Gy in 5 daily fractions to supraclavicular, and axillary regions) following BCS or mastectomy, is non-inferior to conventional fractionation delivered over 3 weeks (40Gy in 15 daily fractions) in patients with node-positive breast cancer. Funded by: Canadian Cancer Society Research Institute
Can-SCAHn: Selective neuroimaging for head-injured emergency patients who take anticoagulant medication.
To derive and validate a head injury clinical decision rule for safe exclusion of traumatic brain injury in 30-50% of head-injured ED patients who take anticoagulant medications. Funded by: Canadian Institutes of Health Research