My research interests and and expertise are in clinical trials. I provide biostatistical and methodological leadership in clinical trials in and have served as the lead biostatistician for several multi-centre trials in various clinical areas including cancer, venous thrombosis, surgery, and emergency medicine. For a list of trials that are coordinated by the Ontario Clinical Oncology Group click here.
I have an interest in oversight committees for clinical trials and have served on several data safety monitoring boards and trial steering committees.
A full list of my publications can be found on can be found on PubMed or Google Scholar.
Sensitivity analysis in clinical trials: three criteria for a valid sensitivity analysis (Eye, 2022)
Diagnosis of deep vein thrombosis with D-dimer adjusted to clinical probability: prospective diagnostic management study (British Medical Journal, 2022)
Perioperative optimization with nutritional supplements in patients undergoing gastrointestinal surgery for cancer: A randomized, placebo-controlled feasibility clinical trial (Surgery, 2022)
A simplified decision rule to rule out deep vein thrombosis using clinical assessment and D-dimer (Journal of Thrombosis & Haemostasis, 2021)
Clinical pre‐test probability adjusted versus age‐adjusted D‐dimer interpretation strategy for DVT diagnosis: A diagnostic individual patient data meta‐analysis (Journal of Thrombosis & Haemostasis, 2020)
Diagnosis of Pulmonary Embolism with d-Dimer Adjusted to Clinical Probability (New England Journal of Medicine, 2019)
Evaluation of a specialized oncology nursing supportive care intervention in newly diagnosed breast and colorectal cancer patients following surgery: a cluster randomized trial (Supportive Cancer Care, 2017)
D-dimer testing to select patients with a first unprovoked venous thromboembolism who can stop anticoagulant therapy: a cohort study (Annals of Internal Medicine, 2015)
Randomized trial of decongestive lymphatic therapy for the treatment of lymphedema in women with breast cancer (Journal of Clinical Oncology, 2013)
Interim cosmetic and toxicity results from RAPID: a randomized trial of accelerated partial breast irradiation using three-dimensional conformal external beam radiation therapy (Journal of Clinical Oncology, 2013)
Selective D-dimer testing for diagnosis of a first suspected episode of deep venous thrombosis: a randomized trial (Annals of Internal Medicine, 2013)
Warfarin dose assessment every 4 weeks versus every 12 weeks in patients with stable international normalized ratios: a randomized trial (Annals of Internal Medicine, 2011)
Competing events in patients with malignant disease who are at risk for recurrent venous thromboembolism (Contemporary Clinical Trials, 2011)
Long-term results of hypofractionated radiation therapy for breast cancer (New England Journal of Medicine, 2010)