Research

Publications

A similar listing can be found on my Google Scholar profile or on PubMed.

2020
Griffiths CD, Xu K, Wang J, McKechnie T, Gafni A, Parpia S, Ruo L, Serrano PE. Laparoscopic hepatectomy is safe and effective for the management of patients with colorectal cancer liver metastases in a population-based analysis in Ontario, Canada. A Retrospective Cohort Study. International Journal of Surgery. 2020; S1743-9191(20)30667-1. doi: 10.1016/j.ijsu.2020.08.052. PMID: 32927139
Shahi J, Peng J, Donovan E, Vansantvoort J, Wong R, Tsakiridis T, Quan K, Parpia S, Swaminath A. Overall and chemotherapy-free survival following stereotactic body radiation therapy for abdominopelvic oligometastases. Journal of Medical Imaging and Radiation Oncology. 2020 ;64(4):563-569. doi: 10.1111/1754-9485.13057. PMID: 32497405
Takada T, van Doorn S, Parpia S, de Wit K, Anderson DR, Stevens SM, Woller SC, Ten Cate-Hoek AJ, Elf JL, Kraaijenhagen RA, Schutgens REG, Wells PS, Kearon C, Moons KGM, Geersing GJ. Diagnosing deep vein thrombosis in cancer patients with suspected symptoms: An individual participant data meta-analysis. Journal of Thrombosis and Haemostasis. 2020 [ePub]. doi: 10.1111/jth.14900. PMID: 32433797
Wang J, Griffiths C, Simunovic M, Parpia S, Gu CS, Gafni A, Ruo L, Hallet J, Bogach J, Serrano PE. Simultaneous versus staged resection for synchronous colorectal liver metastases: A population-based cost analysis in Ontario, Canada – Health economic evaluation. International Journal of Surgery. 2020 [ePub]. doi: 10.1016/j.ijsu.2020.04.044. PMID: 32335234
Arsenault J, Parpia S, Goldberg M, Rakovitch E, Reiter H, Doherty M, Lukka H, Sussman J, Wright J, Julian J, Whelan TJ. Acute Toxicity and Quality of Life of Hypofractionated Radiotherapy for Breast Cancer. International Journal of Radiation Oncology Biology Physics. 2020 [ePub]. doi: 10.1016/j.ijrobp.2020.03.049. PMID: 32334033
de Wit, K., Parpia, S., Varner, C., Worster, A., McLeod, S., Clayton, N., Kearon, C. and Mercuri, M.  Clinical Predictors of Intracranial Bleeding in Older Adults Who Have Fallen: A Cohort Study. Journal of the American Geriatric Society. 2020 [ePub] doi:10.1111/jgs.16338. PMID: 32010977
Medeiros SK, Emery B, Bhagirath V, Parpia S, Dwivedi DJ, Dwivedi NJ, Kearon C, Liaw PC. Does cell-free DNA promote coagulation and inhibit fibrinolysis in patients with unprovoked venous thromboembolism? Thrombosis Research. 2020; 186:13-9. DOI: 10.1016/j.thromres.2019.11.030. PMID: 31838139
Parpia, S, Takach Lapner, S, Schutgens, R, Elf, J, Geersing, G‐J, Kearon, C. Clinical pre‐test probability adjusted versus age‐adjusted D‐dimer interpretation strategy for DVT diagnosis: A diagnostic individual patient data meta‐analysis. Journal of Thrombosis and Haemostasis. 2020; 18: 669– 675. https://doi.org/10.1111/jth.14718. PMID: 31869505
Bogach J, Wang J, Griffiths C, Parpia S, Saskin R, Hallet J, Ruo L, Simunovic M, Serrano P. Simultaneous Versus Staged Resection For Synchronous Colorectal Liver Metastases: A Population-Based Cohort Study. International Journal of Surgery. 2020: 74:68-75. DOI: 10.1016/j.ijsu.2019.12.009. PMID: 31843676
2019
MacColl C, Salehi A, Parpia S, Hodgson N, Ramonas M, Williams P. Benign breast papillary lesions diagnosed on core biopsy: upgrade rate and risk factors associated with malignancy on surgical excision. Virchows Archiv. 2019; 1;475(6):701-7. DOI: 10.1007/s00428-019-02626-5. PMID: 31372738
Kearon C, de Wit K, Parpia S, Schulman S, Afilalo M, Hirsch A, Spencer FA, Sharma S, D’Aragon F, Deshaies JF, Le Gal G. Diagnosis of Pulmonary Embolism with d-Dimer Adjusted to Clinical Probability. New England Journal of Medicine. 2019; 28;381(22):2125-34. DOI: 10.1056/NEJMoa1909159. PMID: 31774957
Griffiths C, Bogach J, Simunovic M, Parpia S, Ruo L, Hallet J, Serrano PE. Simultaneous resection of colorectal cancer with synchronous liver metastases; a practice survey. HPB. 2019 Oct 8. DOI: 10.1016/j.hpb.2019.09.012. PMID: 31601509
Donovan EK, Parpia S, Greenspoon JN. Incidence of radionecrosis in single-fraction radiosurgery compared with fractionated radiotherapy in the treatment of brain metastasis. Current Oncology. 2019; 26(3):e328-e333. DOI: 10.3747/co.26.4749. PMID: 31285676.
Fong C, Parpia S, Yemen B, Tsai S, Greenspoon J. Using Magnetic Resonance Perfusion to Stratify Overall Survival in Treated High-Grade Gliomas. Canadian Journal of Neurological Science. 2019; 46(5):533-539. DOI: 10.1017/cjn.2019.225. PMID: 31284880.
Serrano PE, Parpia S, Valencia M, Simunovic M, Bhandari M, Levine M. Incidence of delayed venous thromboembolic events in patients undergoing abdominal and pelvic surgery for cancer: a systematic review and meta-analysis. ANZ Journal of Surgery. 2019; 89(10):1217-1223. DOI: 10.1111/ans.15290. PMID: 31210407.
Kearon C, Parpia S, Spencer FA, Schulman S, Stevens SM, Shah V, Bauer KA, Douketis JD, Lentz SR, Kessler CM, Connors JM. Long-term risk of recurrence in patients with a first unprovoked venous thromboembolism managed according to D-dimer results; a cohort study. Journal of Thrombosis and Haemostasis. 2019; 17(7):1144-1152. DOI: 10.1111/jth.14458. PMID: 31033194.
Donovan EK, Sienna J, Mitera G, Kumar-Tyagi N, Parpia S, Swaminath A. Single versus multifraction radiotherapy for spinal cord compression: A systematic review and meta-analysis. Journal of the European Society for Therapeutic Radiology and Oncology. 2019; 134:55-66. DOI: 10.1016/j.radonc.2019.01.019. PMID: 31005225
Serrano PE, Carter DN, Li C, Valencia M, Ruo L, Parpia S, Simunovic M, Levine O. Adjuvant Chemotherapy With or Without Biologics Including Antiangiogenics and Monoclonal Antibodies Targeting EGFR and EpCAM in Colorectal Cancer: A Systematic Review and Meta-analysis. Journal of Surgical Research. 2019; 239:14-21. DOI: 10.1016/j.jss.2019.01.030. PMID: 30782542.
Daza JF, Solis NM, Parpia S, Gallinger S, Moulton CA, Belley-Cote EP, Levine MN, Serrano PE. A meta-analysis exploring the role of PET and PET-CT in the management of potentially resectable colorectal cancer liver metastases. European Journal of Surgical Oncology. 2019; DOI: 10.1016/j.ejso.2019.03.025. PMID: 30928334.
Giles AE, Valencia M, Parpia S, Fu E, R Leyo, Simunovic M, Serrano PE. Simultaneous versus staged resection of rectal cancer and synchronous liver metastases (RESECT): A systematic review and meta-analysis. European Surgery. 2019; 1-8. DOI: doi.org/10.1007/s10353-019-0582-0
Sharif S, Eventov M, Kearon C, Parpia S, Li M, Jiang R, Sneath P, Fuentes CO, Marriott C, de Wit K. Comparison of the age-adjusted and clinical probability-adjusted D-dimer to exclude pulmonary embolism in the emergency department. American Journal of Emergency Medicine. 2019; 37(5):845-850. doi: 10.1016/j.ajem.2018.07.053.  PMID: 30077494
2018
Serrano PE, Parpia S, Nair S, Ruo L, Simunovic M, Levine O, Duceppe E, Rodrigues C. Perioperative Optimization With Nutritional Supplements in Patients Undergoing Gastrointestinal Surgery for Cancer (PROGRESS): Protocol for a Feasibility Randomized Controlled Trial. JMIR Research Protocols. 2018; 7(10):e10491. DOI: 10.2196/10491. PMID: 30381282
Serrano PE, Parpia S, Linkins LA, Elit L, Simunovic M, Ruo L, Bhandari M, Levine M. Venous Thromboembolic Events Following Major Pelvic and Abdominal Surgeries for Cancer: A Prospective Cohort Study. Annals of Surgical Oncology. 2018; 26:1-8. DOI: 10.1245/s10434-018-6671-7. PMID: 30051364
Serrano PE, Gafni A, Parpia S, Ruo L, Simunovic M, Meyers BM, Reiter H, Wei A, Gallinger S, Karanicolas P, Hallet J, Devaud N, Levine M. Simultaneous resection of colorectal cancer with synchronous liver metastases (RESECT), a pilot study. International Journal of Surgery Protocols. 2018; 8: 1 – 6. DOI: doi.org/10.1016/j.isjp.2018.01.001
Kearon C., Parpia S., Spencer F. A., Baglin T., Stevens S. M., Bauer K. A., Lentz S. R., Kessler C. M., Douketis J. D., Moll S., Kaatz S., Schulman S., Connors J. M., Ginsberg J. S., Spadafora L., Bhagirath V., Liaw P. C., Weitz J. I., & Julian J. A. Antiphospholipid Antibodies and Recurrent Thrombosis after a First Unprovoked Venous Thromboembolism. Blood. 2018; 31(19):2151-2160.  doi: 10.1182/blood-2017-09-805689. PMID: 29490924
Bogach J, Levine O, Parpia S, Valencia M, Ruo L, Serrano P. Does the Addition of Biologic Agents to Chemotherapy in Patients with Unresectable Colorectal Metastases Result in a Higher Proportion of Patients Undergoing Resection? A Systematic Review of Meta-analysis. Journal of Gastrointestinal Surgery. 2018; 22(3):523-528. doi: 10.1007/s11605-017-3640-6. PMID: 29204907
Sussman J, Bainbridge D, Whelan T, Brazil K, Parpia S, Wiernikowski J, Schiff S, Rodin G, Sergeant M, Howell D. Evaluation of a specialized oncology nursing supportive care intervention in newly diagnosed breast and colorectal cancer patients following surgery: a cluster randomized trial. Supportive Care Cancer. 2018; 26(5):1533-1541. doi: 10.1007/s00520-017-3981-4. PMID: 29189967
2017
Kocovski L, Lee JD, Parpia S, Fernandes J, Nair V. Association of Waist-Hip Ratio to Sudden Cardiac Death and Severe Coronary Atherosclerosis in Medicolegal Autopsies. American Journal of Forensic Medicine and Pathology. 2017; 38(3):226-8. DOI: 10.1097/PAF.0000000000000330. PMID: 28692479
Dayes IS, Parpia S, Gilbert J, Julian JA, Davis IR, Levine MN, Sathya J. Long-Term Results of a Randomized Trial Comparing Iridium Implant Plus External-Beam Radiation Therapy with External-Beam Radiation Therapy Alone in Node-Negative Locally Advanced Cancer of the Prostate. International Journal of Radiation Oncology, Biology & Physics. 2017; 99(1): 90 – 93. doi: 10.1016/j.ijrobp.2017.05.013. PMID: 28816169 
Kucharczyk MJ, Parpia S, Walker-Dilks C, Banfield L, and Swaminath A. Ablative Therapies in Metastatic Breast Cancer: A Systematic Review. Breast Cancer Research and Treatment. 2017; 164 (1):1-13. doi: 10.1007/s10549-017-4228-2. PMID:28401364
Swaminath A, Wierzbicki M, Parpia S, Wright JR, Tsakiridis TK, Okawara GS, Kundapur V, Bujold A, Ahmed N, Hirmiz K, Kurien E, Filion E, Gabos Z, Faria S, Louie AV, Owen T, Wai E, Ramchandar K, Chan EK, Julian JA, Cline K, Whelan TJ.  Canadian Phase III Randomized Trial of Stereotactic Body Radiotherapy Versus Conventionally Hypofractionated Radiotherapy for Stage I, Medically Inoperable Non–Small-Cell Lung Cancer – Rationale and Protocol Design for the Ontario Clinical Oncology Group (OCOG)-LUSTRE Trial. Clinical Lung Cancer. 2017; 18(2): 250-254. doi: 10.1016/j.cllc.2016.08.002.PMID: 27876603
Kucharczyk MJ, Parpia S, Whitton A, Greenspoon JN. Evaluation of pseudoprogression in patients with glioblastoma. Neuro-Oncology Practice. 2017; 4(2): 120-134. doi: 10.1093/nop/npw021  
2016
Kearon, C., Parpia, S., Spencer, F.A., Baglin, T., Stevens, S.M., Bauer, K.A., Lentz, S.R., Kessler, C.M., Douketis, J.D., Moll, S. and Kaatz, S. D-dimer levels and recurrence in patients with unprovoked VTE and a negative qualitative D-dimer test after treatment. Thrombosis Research. 2016; 146:119-125. doi: 10.1016/j.thromres.2016.06.023. PMID: 27354153
Vedantham S, Kahn SR, Goldhaber SZ, Comerota AJ, Parpia S, Meleth S, Earp D, Williams R, Sista AK, Marston W, Rathbun S. Endovascular therapy for advanced post-thrombotic syndrome: Proceedings from a multidisciplinary consensus panel. Vascular Medicine. 2016; 4:400-7. doi: 10.1177/1358863X16650747. PMID: 27247235
Perl J, Parpia S, Nessim SJ. Does the risk of peritoneal dialysis-associated peritonitis vary by time on treatment? Clinical Nephrology. 2016; 85(4):209-14. doi: 10.5414/CN108758. PMID: 26857630
Bates SM, Takach Lapner S, Douketis JD, Kearon C, Julian J, Parpia S, Schulman S, Weitz JI, Linkins LA, Crowther M, Lim W, Spencer FA, Lee AY, Gross PL, Ginsberg J. Rapid Quantitative D-dimer to Exclude Pulmonary Embolism: A Prospective Cohort Management Study. Journal of Thrombrosis & Haemostasis. 2016; 14(3):504-9. doi: 10.1111/jth.13234. PMID: 26707364
Dhutia H, Malhotra A, Parpia S, Gabus V, Finocchiaro G, Mellor G, Merghani A, Millar L, Narain R, Sheikh N, Behr ER, Papadakis M, Sharma S. The prevalence and significance of a short QT interval in 18 825 low-risk individuals including athletes. British Journal of Sports Medicine. 2016; 50(2):124-9. doi: 10.1136/bjsports-2015-094827. PMID: 26400956
2015
Peterson D, Truong PT, Parpia S, Olivotto IA, Berrang T, Kim DH, Kong I, Germain I, Nichol A, Akra M, Roy I, Reed M, Fyles A, Trotter T, Perera F, Balkwill S, Lavertu S, Elliott E, Julian JA, Levine MN, Whelan TJ for the RAPID trial investigators. Predictors of adverse cosmetic outcome in the RAPID trial: an exploratory analysis. International Journal of Radiation Oncology, Biology & Physics. 2015; 91(5):968-76. doi: 10.1016/j.ijrobp.2014.12.040. PMID: 25832689.
Kearon C, Spencer FA, O’Keeffe D, Parpia S, Schulman S, Baglin T, Stevens SM, Kaatz S, Bauer KA, Douketis JD, Lentz SR, Kessler CM, Moll S, Connors JM, Ginsberg JS, Spadafora L, Julian JA. D-dimer Optimal Duration Study Investigators. (2015). D-dimer testing to select patients with a first unprovoked venous thromboembolism who can stop anticoagulant therapy: a cohort study. Annals of Internal Medicine 2015; 162(1):27-34. doi: 10.7326/M14-1275. PMID: 25560712.
2014
Parpia S, Julian JA, Thabane L, Gu C, Whelan TJ, Levine MN. Treatment crossovers in time-to-event non-inferiority randomized trials of radiotherapy in patients with breast cancer. BMJ Open. 2014; 4(10):e006531. doi: 10.1136/bmjopen-2014-006531. PMID: 25344487.
Clemons MJ, Cochrane B, Pond GR, Califaretti N, Chia SK, Dent RA, Song X, Robidoux A, Parpia S, Warr D, Rayson D, Pritchard KI, Levine MN. Randomised, phase II, placebo-controlled, trial of fulvestrant plus vandetanib in postmenopausal women with bone only or bone predominant, hormone-receptor-positive metastatic breast cancer (MBC): the OCOG ZAMBONEY study. Breast Cancer Research & Treatment. 2014; 146(1):153-62. doi: 10.1007/s10549-014-3015-6. PMID: 24924416.
Mbuagbaw L, Thabane M, Vanniyasingam T, Borg Debono V, Kosa S, Zhang S, Ye C, Parpia S, Dennis BB, Thabane L. Improvement in the quality of abstracts in major clinical journals since CONSORT extension for abstracts: a systematic review. Contemporary Clinical Trials. 2014; 38(2):245-50. doi: 10.1016/j.cct.2014.05.012. PMID: 24861557.
Parpia S, Julian JA, Gu C, Thabane L, Levine MN. Interim analysis for binary outcome trials with a long fixed follow-up time and repeated outcome assessments at pre-specified times. Springerplus.  2014; 3:323. doi: 10.1186/2193-1801-3-323. PMID: 25019050.
Bane AL, Whelan TJ, Pond GR, Parpia S, Gohla G, Fyles AW, Pignol JP, Pritchard KI,  Chambers S, Levine MN. Tumor factors predictive of response to hypofractionated radiotherapy in a randomized trial following breast conserving therapy. Annals of Oncology. 2014; 25(5):992-8. doi: 10.1093/annonc/mdu090. PMID: 24562444.
2013
Parpia S, Koval JJ, Donner A. Evaluation of confidence intervals for the kappa statistic when the assumption of marginal homogeneity is violated. Computational Statistics. 2013; 28(6):2709-18.  doi 10.1007/s00180-013-0424-7
Olivotto IA, Whelan TJ, Parpia S, Kim DH, Berrang T, Truong PT, Kong I, Cochrane B, Nichol A, Roy I, Germain I, Akra M, Reed M, Fyles A, Trotter T, Perera F, Beckham W, Levine MN, Julian JA. Interim cosmetic and toxicity results from RAPID: a randomized trial of accelerated partial breast irradiation using three-dimensional conformal external beam radiation therapy. Journal of Clinical Oncology. 2013; 31(32):4038-45. doi: 10.1200/JCO.2013.50.5511. PMID: 23835717
Dayes IS, Whelan TJ, Julian JA, Parpia S, Pritchard KI, D’Souza DP, Kligman L, Reise D, LeBlanc L, McNeely ML, Manchul L, Wiernikowski J, Levine MN. Randomized trial of decongestive lymphatic therapy for the treatment of lymphedema in women with breast cancer. Journal of Clinical Oncology. 2013; 31(30):3758-63. doi: 10.1200/JCO.2012.45.7192. PMID: 24043733
Parpia S, Thabane L, Julian JA, Whelan TJ, Levine MN. Empirical comparison of methods for analyzing multiple time-to-event outcomes in a non-inferiority trial: a breast cancer study. BMC Medical Research Methodology. 2013; 13:44. doi: 10.1186/1471-2288-13-44. PMID: 23517401
Linkins LA, Bates SM, Lang E, Kahn SR, Douketis JD, Julian J, Parpia S, Gross P, Weitz JI, Spencer FA, Lee AY, O’Donnell MJ, Crowther MA, Chan HH, Lim W, Schulman S, Ginsberg JS, Kearon C. Selective D-dimer testing for diagnosis of a first suspected episode of deep venous thrombosis: a randomized trial. Annals of Internal Medicine. 2013; 158(2):93-100. doi: 10.7326/0003-4819-158-2-201301150-00003. PMID: 23318311.
2012
Elit LM, Lee AY, Parpia S, Swystun LL, Liaw PC, Hoskins P, Julian DH, Julian JA, Levine MN. Dalteparin low molecular weight heparin (LMWH) in ovarian cancer: a phase II randomized study. Thrombosis Research. 2012; 130(6):894-900. doi: 10.1016/j.thromres.2012.09.010. PMID: 23046525.
2011
Schulman S, Parpia S, Stewart C, Rudd-Scott L, Julian JA, Levine M. Warfarin dose assessment every 4 weeks versus every 12 weeks in patients with stable international normalized ratios: a randomized trial. Annals of Internal Medicine. 2011; 155(10):653-9, W201-3. doi: 10.7326/0003-4819-155-10-201111150-00003. PMID: 22084331
Parpia S, Julian JA, Thabane L, Lee AY, Rickles FR, Levine MN. Competing events in patients with malignant disease who are at risk for recurrent venous thromboembolism. Contemporary Clinical Trials. 2011; 32(6):829-33. doi: 10.1016/j.cct.2011.07.005. PMID: 21777700
Perry JR, Julian JA, Laperriere NJ, Geerts W, Agnelli G, Rogers LR, Malkin MG, Sawaya R, Baker R, Falanga A, Parpia S, Finch T, Levine MN. PRODIGE: a randomized placebo-controlled trial of dalteparin low-molecular-weight heparin thromboprophylaxis in patients with newly diagnosed malignant glioma. Journal of Thrombosis & Haemostasis. 2010; 8(9):1959-65. doi: 10.1111/j.1538-7836.2010.03973.x. PMID: 20598077
2010
Whelan TJ, Pignol JP, Levine MN, Julian JA, MacKenzie R, Parpia S, Shelley W, Grimard L, Bowen J, Lukka H, Perera F, Fyles A, Schneider K, Gulavita S, Freeman C. Long-term results of hypofractionated radiation therapy for breast cancer. New England Journal of Medicine. 2010; 362(6):513-20. doi: 10.1056/NEJMoa0906260. PMID: 20147717